FAN1抗体;FAN1 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P13392(FAN1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

FAN1 (Fanconi anemia-associated nuclease 1) is a DNA repair protein critical for maintaining genomic stability. It functions as a structure-specific endonuclease involved in resolving DNA interstrand crosslinks (ICLs), which are toxic lesions obstructing DNA replication and transcription. FAN1 operates within the Fanconi anemia (FA) pathway, a network of proteins coordinating ICL repair, though it is not a core FA gene. Mutations in FAN1 are linked to karyomegalic interstitial nephritis, chronic kidney disease, and cancer susceptibility, highlighting its role in cellular homeostasis.

FAN1 antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies enable detection of FAN1 protein levels via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers use them to explore FAN1's involvement in DNA damage response, replication fork stability, and mitotic progression. Commercial FAN1 antibodies are typically raised against specific epitopes (e.g., human FAN1 N-terminal or C-terminal regions) and validated for species reactivity (human, mouse, rat). Both monoclonal and polyclonal variants exist, with applications spanning basic research, biomarker studies, and therapeutic target validation. Reliable FAN1 antibodies are crucial for elucidating its role in disease mechanisms and potential therapeutic strategies.