FAM50A抗体;FAM50A Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate , Primary antibody: P13387(FAM50A Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P13387(FAM50A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

FAM50A (Family with sequence similarity 50 member A) is a nuclear protein encoded by the FAM50A gene, located on the X chromosome (Xq28). It belongs to the FAM50 family, which includes FAM50B and FAM50C, though its precise molecular functions remain incompletely characterized. Studies suggest FAM50A may play roles in RNA processing, cell cycle regulation, and DNA damage response, potentially interacting with splicing factors or transcriptional regulators. Its expression is detected in various tissues, with higher levels observed in the brain, testes, and proliferating cells.

FAM50A antibodies are essential tools for investigating the protein's localization, expression patterns, and interactions. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study FAM50A dynamics during cellular processes or disease states. Research has linked FAM50A dysregulation to cancer (e.g., hepatocellular carcinoma, breast cancer) and neurodevelopmental disorders, with some studies proposing it as a potential biomarker. However, functional insights remain limited, necessitating further exploration. Commercial FAM50A antibodies are typically raised against specific epitopes, often validated using knockout cell lines to confirm specificity. Recent interest in FAM50A has grown due to its possible involvement in X-linked intellectual disability disorders and sex chromosome aneuploidy phenotypes.