FAM20C抗体;FAM20C Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13384(FAM20C Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

**Background of FAM20C Antibody**

FAM20C (Family with sequence similarity 20. member C) is a Golgi-localized kinase essential for regulating secretory pathway phosphorylation. It phosphorylates numerous secreted proteins involved in biomineralization, cell differentiation, and tissue homeostasis, including osteopontin, dentin matrix protein 1. and caseins. Mutations in *FAM20C* are linked to Raine syndrome, a rare autosomal recessive disorder characterized by abnormal bone development and craniofacial defects.

FAM20C antibodies are crucial tools for studying its expression, localization, and functional roles. These antibodies are typically generated against specific epitopes of the human FAM20C protein and are validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They help detect FAM20C in tissues such as bone, teeth, and kidneys, where it plays a key role in phosphate metabolism and mineralization.

Research using FAM20C antibodies has clarified its involvement in pathological conditions like osteomalacia, vascular calcification, and dental anomalies. Additionally, studies explore FAM20C's interaction with FAM20A (a co-regulator) and its broader impact on the "secreted phosphoproteome." Reliable FAM20C antibodies are vital for dissecting molecular mechanisms in skeletal biology and evaluating therapeutic strategies targeting mineralization disorders.