USP16抗体;USP16 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13367(USP16 Antibody) at dilution 1/75. (Original magnification: ×200)    

  
  

The USP16 antibody is a key research tool used to study the ubiquitin-specific protease 16 (USP16), a deubiquitinating enzyme (DUB) belonging to the ubiquitin-specific protease (USP) family. USP16 plays critical roles in regulating cellular processes such as cell cycle progression, DNA damage repair, chromatin remodeling, and stem cell differentiation by removing ubiquitin moieties from target proteins. It is implicated in modulating histone H2A ubiquitination, a post-translational modification essential for transcriptional regulation and genome stability. Dysregulation of USP16 has been linked to various diseases, including cancers, neurodegenerative disorders, and developmental abnormalities.

USP16 antibodies are widely employed in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect USP16 expression levels, localization, and interaction partners. These antibodies are critical for investigating USP16's functional mechanisms in both normal physiology and disease contexts. Researchers often validate USP16 antibodies using knockout cell lines or siRNA-mediated knockdown to ensure specificity, as cross-reactivity with other USP family members can occur. Commercial USP16 antibodies are typically developed in hosts like rabbits or mice, with monoclonal or polyclonal formats available. Their applications span basic research in cell biology, cancer studies, and stem cell research, aiding in the exploration of USP16's role in maintaining cellular homeostasis and its potential as a therapeutic target.