基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 EXOSC9抗体 EXOSC9抗体
  • EXOSC9抗体;EXOSC9 Antibody—艾普蒂
  • EXOSC9抗体;EXOSC9 Antibody—艾普蒂
  • EXOSC9抗体;EXOSC9 Antibody—艾普蒂

1/3

EXOSC9抗体;EXOSC9 Antibody—艾普蒂

Rabbit Polyclonal EXOSC9 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-28

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
EXOSC9抗体
英文名称：
Rabbit Polyclonal EXOSC9 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 7230 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
EXOSC9

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/40-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

Aliasesp5; p6; RRP45; PMSCL1; Rrp45p; PM/Scl-75
WB Predicted band size49 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human EXOSC9
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human heart tissue, HEPG2 and 293T cell lysates, Primary antibody: P13365(EXOSC9 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13365(EXOSC9 Antibody) at dilution 1/35. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P13365(EXOSC9 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是3篇与EXOSC9抗体相关的参考文献及其摘要概括：

---

1. **文献名称**: "EXOSC9 mutations disrupt RNA exosome causing cerebellar degeneration and motor dysfunction"

**作者**: Wan J. et al.

**摘要**: 该研究通过全外显子测序发现EXOSC9突变导致小脑退行性病变，利用特异性抗体证实突变体蛋白稳定性下降，并揭示其通过破坏RNA外切体功能引发神经元RNA代谢异常。

---

2. **文献名称**: "The RNA exosome subunit EXOSC9 is a potential prognostic biomarker in glioblastoma"

**作者**: Chen L. et al.

**摘要**: 研究通过免疫组化(EXOSC9抗体)分析胶质母细胞瘤样本，发现EXOSC9高表达与患者生存期缩短显著相关，提示其可作为预后标志物及潜在治疗靶点。

---

3. **文献名称**: "Structural insights into the RNA exosome complex by anti-EXOSC9 immunoprecipitation"

**作者**: Schmidt K. et al.

**摘要**: 采用EXOSC9抗体进行免疫共沉淀结合冷冻电镜技术，解析外切体复合体三维结构，阐明EXOSC9亚基在底物RNA识别及催化中的关键作用。

---

注：上述文献为示例，实际引用需根据具体数据库检索结果调整。建议通过PubMed或Google Scholar以“EXOSC9 antibody” + “function/disease/structure”等关键词获取最新文献。

       

背景信息

The EXOSC9 antibody is a tool used to detect the EXOSC9 protein, a critical component of the RNA exosome complex. This evolutionarily conserved multi-subunit complex plays a central role in RNA processing, surveillance, and degradation. Specifically, EXOSC9 (Exosome Component 9), also known as PM/Scl-75 or Rrp45. functions as a structural and catalytic subunit within the exosome’s core. It contributes to 3'→5' exoribonuclease activity, essential for trimming or degrading various RNA substrates, including ribosomal RNA (rRNA), small nuclear RNA (snRNA), and damaged mRNAs.

Mutations or dysregulation of EXOSC9 are linked to human diseases. For example, it is associated with pontocerebellar hypoplasia type 1D (PCH1D), a severe neurodevelopmental disorder, and autoimmune conditions like the PM/Scl overlap syndrome. Autoantibodies against EXOSC9 are occasionally found in patients with systemic sclerosis or dermatomyositis, making it a biomarker of interest.

The EXOSC9 antibody is widely used in research to study RNA metabolism, gene expression regulation, and disease mechanisms. It enables detection of EXOSC9 expression levels via Western blotting, immunofluorescence, or immunoprecipitation. Commercially available antibodies are often validated for specificity in human, mouse, or rat samples. Researchers also employ it to investigate exosome assembly, substrate targeting, and interactions with cofactors like MTR4 or SKIV2L. Its applications extend to exploring therapeutic strategies for exosome-related disorders.

       
EXOSC9抗体;EXOSC9;EXOSC9 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

EXOSC9抗体相关厂家报价

  • 抗CRF抗体
  • 抗CRF抗体
  • 维百奥（北京）生物科技有限公司 VIP
  • 2026-03-02
  • 询价
内容声明
official 进入官方账号
拨打电话 立即询价