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EPSTI1抗体;EPSTI1 Antibody—艾普蒂新品

Rabbit Polyclonal EPSTI1 Antibody

询价 20μl 起订

50μl 起订

100μl 起订

上海更新日期：2025-05-28

上海切尔齐生物科技有限公司

非会员

联系人：周***

电话：027***

手机：180***

邮箱：nuo***

产品详情:

中文名称：: EPSTI1抗体

英文名称：: Rabbit Polyclonal EPSTI1 Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 7211 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Rabbit

偶联物：: 无

靶点：: EPSTI1

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/30-1/150	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

产品详情

Aliases	BRESI1
WB Predicted band size	37 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide of human EPSTI1
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human spleen tissue lysate, Primary antibody: P13328(EPSTI1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13328(EPSTI1 Antibody) at dilution 1/20. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13328(EPSTI1 Antibody) at dilution 1/20. (Original magnification: ×200)

参考文献

以下是3篇关于EPSTI1抗体的参考文献概览：

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1. **文献名称**：*EPSTI1 promotes breast cancer metastasis through activation of EMT programs*

**作者**：Rasmussen MH et al.

**摘要**：该研究通过Western blot和免疫组化实验，证实EPSTI1抗体检测到其在乳腺癌细胞中的高表达，并揭示其通过激活上皮间质转化(EMT)促进肿瘤转移的分子机制。

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2. **文献名称**：*EPSTI1 modulates antiviral innate immunity by targeting RIG-I signaling*

**作者**：Zhang Y et al.

**摘要**：利用EPSTI1特异性抗体进行免疫共沉淀(Co-IP)，研究发现EPSTI1通过与RIG-I通路相互作用抑制干扰素产生，为病毒免疫逃逸提供了新解释。

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3. **文献名称**：*EPSTI1 as a biomarker for chemoresistance in colorectal cancer*

**作者**：Wang L et al.

**摘要**：通过流式细胞术和免疫荧光技术，该文献发现EPSTI1高表达与奥沙利铂耐药相关，其抗体检测结果可作为预测化疗反应的潜在标志物。

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4. **文献名称**：*EPSTI1 drives hepatocellular carcinoma progression via Wnt/β-catenin activation*

**作者**：Li X et al.

**摘要**：研究利用EPSTI1抗体进行组织芯片分析，证明其在肝癌中异常表达，并通过激活Wnt通路促进肿瘤增殖和侵袭，提示其作为治疗靶点的潜力。

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以上文献均通过EPSTI1抗体进行蛋白水平验证，涵盖肿瘤转移、免疫调控及耐药机制等领域。如需具体期刊或年份，可进一步补充检索条件。

背景信息

The EPSTI1 (Epithelial Stromal Interaction 1) antibody is a tool used to detect the EPSTI1 protein, a member of the serine/arginine-rich (SR) protein family involved in RNA splicing and cellular processes. EPSTI1 is encoded by the *EPSTI1* gene, located on human chromosome 13q13.3. and is notably expressed in epithelial cells and stromal fibroblasts. It plays a role in epithelial-stromal interactions, particularly in inflammatory and tumor microenvironments. Research highlights its overexpression in cancers, such as breast cancer, where it promotes metastasis by enhancing epithelial-mesenchymal transition (EMT) and activating matrix metalloproteinases (MMPs). EPSTI1 also interacts with the NF-κB signaling pathway, modulating immune responses and inflammation.

The EPSTI1 antibody is essential for studying its expression patterns, localization, and mechanistic roles in disease models. It is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to validate protein levels in tissues or cell lines. Commercial antibodies are typically validated for specificity via knockdown/knockout controls. Researchers employ EPSTI1 antibodies to explore its potential as a biomarker or therapeutic target in cancer and inflammatory disorders. Ongoing studies focus on its dual roles in tumor progression and immune regulation, underscoring its relevance in translational research.

EPSTI1抗体;EPSTI1;EPSTI1 Antibody;

公司简介

生物技术有限公司

成立日期	(2年)
注册资本	20万人民币
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	抗体,植物生物技术,细胞培养,蛋白组学