EMX1抗体;EMX1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13319(EMX1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13319(EMX1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The EMX1 antibody is a crucial tool in developmental biology and neuroscience research, targeting the Empty Spiracles Homeobox 1 (EMX1) protein, a transcription factor encoded by the *EMX1* gene. EMX1 belongs to the homeobox gene family, which plays pivotal roles in embryonic development, particularly in the formation of the cerebral cortex, urogenital system, and skeletal structures. It is highly expressed during early neurogenesis, regulating regional identity, neuronal differentiation, and patterning of the forebrain. EMX1 mutations or dysregulation have been linked to neurological disorders, including brain malformations and intellectual disabilities, as well as urogenital abnormalities.

Researchers use EMX1 antibodies primarily in immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to visualize protein localization and expression levels in tissues or cell lines. These applications are vital for studying brain development, neural stem cell dynamics, and disease mechanisms. The antibody also aids in validating *EMX1* knockout models, as loss of EMX1 protein correlates with specific developmental defects. Commercial EMX1 antibodies are typically raised against conserved epitopes, with validation across species like humans, mice, and rats. However, users must verify specificity using controls like knockout samples due to potential cross-reactivity with related homeodomain proteins. Its utility extends to cancer research, where EMX1’s role in tumor suppression or progression is under investigation.