TMEM45A抗体;TMEM45A Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13318(TMEM45A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13318(TMEM45A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The TMEM45A (Transmembrane Protein 45A) antibody is a research tool designed to detect and study the expression of the TMEM45A protein, a poorly characterized transmembrane protein implicated in various physiological and pathological processes. TMEM45A is encoded by the TMEM45A gene located on human chromosome 3q29 and is predicted to span cellular membranes multiple times, though its exact structure remains under investigation. Studies suggest its involvement in keratinocyte differentiation, lipid metabolism, and tumor progression, particularly in cancers such as breast, cervical, and hepatocellular carcinoma. Elevated TMEM45A expression has been associated with chemotherapy resistance in certain cancers, making it a potential biomarker or therapeutic target.

The antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It enables detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the localization of TMEM45A in tissues or cultured cells. Validation includes testing for specificity through knockout controls or siRNA knockdown. Researchers use this antibody to explore TMEM45A's role in cellular stress responses, epidermal barrier formation, and cancer metastasis mechanisms. Despite its growing utility, further studies are needed to fully elucidate TMEM45A's molecular interactions and clinical relevance. Commercial antibodies vary in clonality (monoclonal/polyclonal) and recommended applications, necessitating careful selection based on experimental requirements.