ELP4抗体;ELP4 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13312(ELP4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13312(ELP4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The ELP4 (Elongator Complex Protein 4) antibody targets a subunit of the Elongator complex, a conserved multi-protein assembly involved in transcriptional regulation and post-transcriptional tRNA modification. ELP4. along with other Elongator subunits (ELP1-6), plays a critical role in histone acetylation, chromatin remodeling, and the modification of wobble uridines in tRNA, which influences translational efficiency and fidelity. Dysregulation of ELP4 has been linked to neurodevelopmental disorders, including autism spectrum disorders and intellectual disabilities, as well as certain cancers.

ELP4 antibodies are widely used in research to study the protein's expression, localization, and functional interactions. They facilitate techniques such as Western blotting, immunoprecipitation, and immunohistochemistry, enabling investigations into Elongator's role in cellular processes like neuronal development, DNA damage response, and metabolic regulation. Studies using ELP4-specific antibodies have also explored its association with diseases, such as Rolandic epilepsy, where ELP4 mutations or altered expression may disrupt neural network formation.

Available as monoclonal or polyclonal variants, ELP4 antibodies are critical tools for dissecting the molecular mechanisms of the Elongator complex and its broader implications in health and disease. Ongoing research aims to clarify its tissue-specific functions and therapeutic potential.