DUSP27抗体;DUSP27 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13287(DUSP27 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P13287(DUSP27 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The DUSP27 antibody is designed to target dual-specificity phosphatase 27 (DUSP27), also known as VHP or DUSP25. a member of the protein tyrosine phosphatase (PTP) family. DUSP27 is classified as an atypical dual-specificity phosphatase due to its unique structure and substrate specificity. Unlike other DUSPs that primarily regulate mitogen-activated protein kinase (MAPK) signaling, DUSP27 lacks the conserved N-terminal MAPK-binding domain, suggesting divergent regulatory roles. It is predominantly expressed in tissues such as the heart, skeletal muscle, and kidney, and has been implicated in cellular processes like oxidative stress response, insulin signaling, and metabolic regulation. Studies indicate its potential involvement in diabetes, cardiovascular diseases, and cancer, though its precise molecular mechanisms remain under investigation.

Antibodies against DUSP27 are essential tools for elucidating its biological functions. They enable the detection and quantification of DUSP27 expression in various experimental models via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Polyclonal or monoclonal DUSP27 antibodies, often raised in rabbits or mice, are validated for specificity to ensure minimal cross-reactivity with other phosphatases. Recent research has utilized these antibodies to explore DUSP27's role in disease contexts, such as its downregulation in diabetic cardiomyopathy or aberrant expression in certain tumors. Ongoing efforts aim to clarify its interactions with substrates and pathways, positioning DUSP27 as a potential therapeutic target. The development of reliable antibodies continues to advance our understanding of its physiological and pathological significance.