DOCK11抗体;DOCK11 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13282(DOCK11 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P13282(DOCK11 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The DOCK11 antibody is a tool used to detect and study Dedicator of Cytokinesis 11 (DOCK11), a protein belonging to the DOCK family of guanine nucleotide exchange factors (GEFs). DOCK11. also known as Zizimin2. specifically activates the Rho GTPase CDC42 by catalyzing the exchange of GDP for GTP, regulating cellular processes like cytoskeletal reorganization, cell migration, and polarity. It plays critical roles in immune cell trafficking, neuronal development, and cancer metastasis.

DOCK11 antibodies are essential for investigating its expression, localization, and function in various biological contexts. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to explore DOCK11's involvement in signaling pathways and disease mechanisms. For instance, studies have linked DOCK11 dysregulation to pathologies like immunodeficiency disorders, autoimmune diseases, and tumor progression.

Commercial DOCK11 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the protein's conserved DOCK homology region (DHR-2 domain) or other functional regions. Researchers must validate these antibodies for specificity and cross-reactivity, as DOCK family members share structural similarities. Recent advances in structural biology and genetic models (e.g., CRISPR/Cas9) have further clarified DOCK11's roles, driving demand for reliable antibodies in both basic and translational research.