DOC2B抗体;DOC2B Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13280(DOC2B Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

DOC2B (Double C2-like domain protein Beta) is a calcium-binding protein involved in intracellular vesicle trafficking and neurotransmitter release. It belongs to the DOC2 protein family, characterized by tandem C2 domains (C2A and C2B) that mediate calcium-dependent membrane interactions. DOC2B primarily localizes to synaptic vesicles and secretory granules, playing a critical role in calcium-triggered exocytosis by cooperating with SNARE proteins and synaptotagmin. Its expression is prominent in neuronal tissues, endocrine cells, and certain exocrine systems.

Antibodies targeting DOC2B are essential tools for studying its function in cellular secretion pathways and synaptic transmission. They enable detection of DOC2B expression levels, subcellular localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Research using DOC2B antibodies has linked the protein to neurodevelopmental disorders, epilepsy, and endocrine dysregulation. Altered DOC2B expression has also been observed in cancers, suggesting roles in tumor cell secretion or signaling. Commercial DOC2B antibodies are typically raised against specific epitopes, such as the N-terminal or C2 domains, with validation in knockout models to ensure specificity. These reagents continue to advance understanding of calcium-regulated secretion mechanisms and related pathologies.