DMAP1抗体;DMAP1 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: RAW and NIH/3T3 cell lysates, Primary antibody: P13273(DMAP1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13273(DMAP1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13273(DMAP1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of DMAP1 Antibody**

The DMAP1 (DNA Methyltransferase 1-Associated Protein 1) antibody is a research tool used to study the role of DMAP1. a multifunctional protein involved in chromatin remodeling, transcriptional regulation, and DNA repair. DMAP1 interacts with DNA methyltransferase 1 (DNMT1), forming part of a complex that mediates DNA methylation, a key epigenetic modification critical for gene silencing, genomic imprinting, and X-chromosome inactivation. Beyond its association with DNMT1. DMAP1 also binds to components of histone acetyltransferase (HAT) complexes, such as TIP60. linking DNA methylation to histone modification processes.

DMAP1 antibodies are widely utilized in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect DMAP1 expression, localization, and interaction partners in various biological contexts. Studies using these antibodies have revealed DMAP1's involvement in cell cycle progression, apoptosis, and response to DNA damage. Dysregulation of DMAP1 has been implicated in cancers and developmental disorders, underscoring its importance in maintaining genomic stability and proper epigenetic regulation.

By enabling precise detection of DMAP1. these antibodies contribute to advancing research on epigenetic mechanisms, cancer biology, and potential therapeutic targets.