DIXDC1抗体;DIXDC1 Antibody—艾普蒂 新品

The DIXDC1 (Dishevelled-AXIN domain-containing protein 1) antibody is a tool used to detect and study the DIXDC1 protein, which plays a role in regulating cell adhesion, migration, and signaling pathways. DIXDC1 contains a conserved DIX domain, shared with proteins like Dishevelled (Dvl) and AXIN, linking it to Wnt signaling regulation. It interacts with cytoskeletal components and modulates focal adhesion dynamics, influencing cell motility and cancer metastasis. Research highlights its dual roles: in some contexts, it suppresses tumor invasion by stabilizing cell-matrix adhesions, while in others, it promotes cancer progression via MAPK/ERK pathway activation. DIXDC1 is also implicated in neurodevelopment, affecting dendritic spine formation and synaptic function, with studies suggesting associations with autism spectrum disorders. The antibody is utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore DIXDC1's expression patterns, subcellular localization, and mechanistic contributions in diseases. Its development aids in clarifying DIXDC1's context-dependent functions and potential as a therapeutic target, particularly in oncology and neurological research.