DHRS4抗体;DHRS4 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13264(DHRS4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P13264(DHRS4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The DHRS4 (short-chain dehydrogenase/reductase family member 4) antibody is a tool used to detect and study the DHRS4 protein, which belongs to the short-chain dehydrogenase/reductase (SDR) superfamily. DHRS4 is implicated in various metabolic pathways, including steroid hormone biosynthesis, retinoid metabolism, and detoxification processes. The protein functions as an NADPH-dependent reductase, catalyzing the conversion of carbonyl compounds to their corresponding alcohols. It is encoded by the DHRS4 gene located on human chromosome 1 (1p36.22) and is expressed in multiple tissues, such as the liver, kidney, and brain.

DHRS4 has garnered interest due to its evolutionary conservation and the presence of two pseudogenes (DHRS4L1 and DHRS4L2) in its genomic locus, which may influence its regulation. Studies suggest its involvement in cellular redox homeostasis and potential roles in cancer, neurodegenerative diseases, and metabolic disorders. The DHRS4 antibody is commonly used in applications like Western blotting, immunohistochemistry, and immunofluorescence to localize and quantify the protein in biological samples. Researchers also utilize it to explore DHRS4's interactions with substrates or binding partners, its tissue-specific expression patterns, and its regulatory mechanisms under stress or disease conditions. Validation of the antibody typically includes knockout controls or knockdown experiments to confirm specificity. Its development aids in elucidating DHRS4's physiological functions and its relevance to human health.