基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 CYB5R3 Antibody CYB5R3抗体
  • CYB5R3抗体;CYB5R3 Antibody—艾普蒂
  • CYB5R3抗体;CYB5R3 Antibody—艾普蒂
  • CYB5R3抗体;CYB5R3 Antibody—艾普蒂

1/3

CYB5R3抗体;CYB5R3 Antibody—艾普蒂

Rabbit Polyclonal CYB5R3 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-28

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
CYB5R3抗体
英文名称：
Rabbit Polyclonal CYB5R3 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 7143 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CYB5R3

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesB5R; DIA1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CYB5R3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13221(CYB5R3 Antibody) at dilution 1/50. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P13221(CYB5R3 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是3篇与CYB5R3抗体相关的文献摘要信息：

---

1. **文献名称**：*"NADH-cytochrome b5 reductase 3 (CYB5R3) promotes tumor growth and metastasis in breast cancer by regulating mitochondrial iron metabolism"*

**作者**：Chen et al. (2021)

**摘要**：研究利用CYB5R3特异性抗体，发现其在乳腺癌中通过调节线粒体铁代谢促进肿瘤生长和转移，高表达CYB5R3与患者预后不良相关。

2. **文献名称**：*"Immunohistochemical analysis of CYB5R3 in human colorectal cancer: association with oxidative stress and chemoresistance"*

**作者**：Sato et al. (2018)

**摘要**：通过CYB5R3抗体的免疫组化分析，发现其在结直肠癌中高表达，与氧化应激增强和化疗耐药性相关，提示其作为治疗靶点的潜力。

3. **文献名称**：*"Functional characterization of CYB5R3 mutations in recessive congenital methemoglobinemia"*

**作者**：Shirabe et al. (1995)

**摘要**：利用CYB5R3抗体进行Western blot和酶活性检测，揭示遗传性高铁血红蛋白血症患者的CYB5R3基因突变导致酶功能缺陷的分子机制。

---

以上文献均涉及CYB5R3抗体在疾病机制或功能研究中的应用，涵盖癌症、代谢紊乱等领域。如需具体DOI或期刊信息可进一步补充。

       

背景信息

The CYB5R3 antibody targets cytochrome b5 reductase 3 (CYB5R3), a critical enzyme involved in electron transfer reactions. CYB5R3 exists in two isoforms: a soluble form in erythrocytes and a membrane-bound form in mitochondria and endoplasmic reticulum. It plays a key role in reducing ferric hemoglobin (methemoglobin) to functional ferrous hemoglobin, maintaining oxygen-carrying capacity. Additionally, it participates in fatty acid desaturation, cholesterol synthesis, and drug metabolism by interacting with cytochrome b5.

Mutations in the CYB5R3 gene are linked to recessive congenital methemoglobinemia (Types I and II), characterized by cyanosis and neurological complications. Type II, involving systemic enzyme deficiency, is particularly severe. CYB5R3 dysregulation has also been implicated in cancer, neurodegenerative diseases, and metabolic disorders.

CYB5R3 antibodies are essential tools for studying enzyme expression, localization, and function. They enable detection via Western blotting, immunohistochemistry, and flow cytometry, aiding in research on oxygen metabolism, redox biology, and disease mechanisms. Commercial antibodies are typically validated for specificity against human, mouse, or rat CYB5R3 isoforms. Recent studies also explore its role as a potential biomarker or therapeutic target in conditions like cancer and Alzheimer’s disease.

       
CYB5R3抗体;CYB5R3;CYB5R3 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

CYB5R3抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价