NR2F1抗体;NR2F1 Antibody—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T and NIH/3T3 cell lysates, Primary antibody: P13211(NR2F1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13211(NR2F1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The nuclear receptor subfamily 2 group F member 1 (NR2F1), also known as COUP-TFI (Chicken Ovalbumin Upstream Promoter Transcription Factor I), is a transcription factor belonging to the steroid/thyroid hormone receptor superfamily. It plays critical roles in embryonic development, cellular differentiation, and organogenesis, particularly in the nervous system, eye development, and cardiovascular formation. NR2F1 regulates gene expression by binding to specific DNA response elements, either as a monomer, homodimer, or heterodimer with other nuclear receptors. It is involved in maintaining stem cell pluripotency, neuronal patterning, and angiogenesis. Dysregulation of NR2F1 has been linked to developmental disorders (e.g., Bosch-Boonstra-Schaaf optic atrophy syndrome), cancer progression (acting as either an oncogene or tumor suppressor depending on context), and neurological conditions.

NR2F1 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, immunofluorescence, and chromatin immunoprecipitation (ChIP). These antibodies are typically developed against specific epitopes of the NR2F1 protein, with validation including knockout controls, species cross-reactivity checks, and functional assays. Both monoclonal and polyclonal variants are available, with host species ranging from rabbit and mouse to goat. Researchers must verify antibody specificity for their experimental models, as cross-reactivity with homologous proteins (e.g., NR2F2/COUP-TFII) may occur. Commercial NR2F1 antibodies often include validated application-specific data, supporting their use in developmental biology, cancer research, and neurological studies.