BOP1抗体;BOP1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13206(BOP1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The BOP1 antibody is a tool used in molecular biology to study the BOP1 (Block of Proliferation 1) protein, a conserved component of the PeBoW complex (comprising BOP1. PES1. and WDR12). This complex plays a critical role in ribosome biogenesis, specifically in processing precursor ribosomal RNA (rRNA) and ensuring the maturation of the 60S ribosomal subunit. BOP1 is essential for cell proliferation, as it regulates the nucleolar steps of rRNA maturation, particularly the cleavage of 28S rRNA. Dysregulation of BOP1 has been linked to ribosomopathies, cell cycle defects, and cancer.

BOP1 antibodies are commonly used in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies utilizing these antibodies have highlighted BOP1's role in maintaining genomic stability and its overexpression in certain cancers, suggesting potential as a biomarker or therapeutic target. Additionally, BOP1 depletion or mutation leads to nucleolar stress, activating p53-dependent cell cycle arrest or apoptosis. The antibody's specificity and reliability make it vital for exploring ribosome assembly mechanisms, cancer biology, and cellular stress responses.