ETS1抗体;ETS1 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13204(ETS1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13204(ETS1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The ETS1 antibody is a key tool in molecular and cellular biology research, targeting the ETS1 protein, a member of the E26 transformation-specific (ETS) family of transcription factors. ETS1 regulates gene expression by binding to DNA sequences containing a GGAA/T core motif, playing critical roles in cell proliferation, differentiation, apoptosis, angiogenesis, and immune regulation. It is particularly vital in lymphoid development, T-cell activation, and endothelial cell function. Dysregulation of ETS1 is implicated in cancers (e.g., leukemia, breast cancer), autoimmune diseases, and vascular disorders, making it a focus in disease mechanism studies.

ETS1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions. These antibodies help identify ETS1’s role in signaling pathways, such as MAPK/ERK, and its interplay with other transcription factors. High-quality ETS1 antibodies are validated for specificity, often using knockout controls, to ensure reliable results in both basic research and clinical applications. Their development and optimization continue to advance understanding of ETS1’s dual roles as an oncogene or tumor suppressor, depending on cellular context, aiding therapeutic target discovery.