CNGA4抗体;CNGA4 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebrum tissue and Human cerebella tissue lysates, Primary antibody: P13201(CNGA4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13201(CNGA4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The CNGA4 antibody targets the cyclic nucleotide-gated channel alpha-4 (CNGA4), a subunit of the cyclic nucleotide-gated (CNG) ion channel family. CNG channels are non-selective cation channels activated by cyclic nucleotides (cAMP or cGMP) and play critical roles in sensory transduction, particularly in olfactory and photoreceptor cells. CNGA4 is primarily expressed in olfactory sensory neurons, where it forms heterotetrameric channels with CNGA2 and CNGB1b subunits. Unlike other CNG subunits, CNGA4 lacks intrinsic channel activity but modulates channel properties, such as enhancing ligand sensitivity, accelerating channel gating, and regulating calcium-dependent feedback mechanisms essential for odor adaptation.

Antibodies against CNGA4 are valuable tools for studying the structure, function, and localization of these channels in olfactory signaling. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CNGA4 expression patterns in tissues or cellular models. Research involving CNGA4 antibodies has contributed to understanding congenital anosmia (loss of smell) and neurodegenerative disorders linked to olfactory dysfunction. Additionally, these antibodies aid in exploring channelopathies—diseases caused by ion channel malfunctions—and potential therapeutic targets. Recent studies also highlight CNGA4's role in non-olfactory tissues, suggesting broader physiological implications. Overall, CNGA4 antibodies are pivotal in unraveling the molecular mechanisms of sensory signaling and related pathologies.