CSNK1G1抗体;CSNK1G1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13199(CSNK1G1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The CSNK1G1 antibody targets casein kinase 1 gamma 1 (CK1γ1), a member of the CK1 serine/threonine kinase family. CK1γ1. encoded by the *CSNK1G1* gene, plays roles in Wnt/β-catenin signaling, circadian rhythm regulation, and cell proliferation. It phosphorylates key substrates like Dishevelled (DVL) to modulate Wnt pathway activity, influencing embryonic development and tissue homeostasis. Aberrant CK1γ1 expression is linked to cancers, neurodegenerative diseases, and metabolic disorders, making it a research focus for therapeutic targeting.

CSNK1G1 antibodies are typically monoclonal or polyclonal, generated using immunogenic peptides from conserved regions of the human CK1γ1 protein. They are validated for applications like Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. Specificity is confirmed via knockout controls or siRNA knockdown. These antibodies aid in studying CK1γ1’s localization, expression levels, and interactions in disease models. Commercial variants often include species reactivity details (human, mouse, rat) and compatibility with specific experimental conditions. Researchers use them to explore CK1γ1’s regulatory mechanisms and its potential as a biomarker or drug target. Proper validation remains critical due to kinase family homology and splice variant diversity.