CCL5抗体;CCL5 Antibody—艾普蒂

CCL5 (C-C motif chemokine ligand 5), also known as RANTES (Regulated on Activation, Normal T-cell Expressed and Secreted), is a small chemokine protein involved in immune responses, particularly in recruiting leukocytes like T cells, monocytes, and eosinophils to inflammation sites. It binds to CCR1. CCR3. and CCR5 receptors, playing roles in inflammatory diseases, viral infections (e.g., HIV), and cancer progression. CCL5 antibodies are essential tools for studying its expression, function, and interaction with receptors. These antibodies are widely used in immunoassays (ELISA, Western blot), immunohistochemistry, and flow cytometry to detect CCL5 in biological samples. In therapeutic research, neutralizing CCL5 antibodies are explored to inhibit its pro-inflammatory or tumor-promoting effects, potentially treating conditions like arthritis, asthma, or metastatic cancers. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes. Challenges include ensuring minimal cross-reactivity with related chemokines and optimizing in vivo stability for clinical applications. Understanding CCL5's dual role (protective vs. pathogenic) remains critical for developing targeted antibody-based therapies.