CGAS抗体;CGAS Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13163(CGAS Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of cGAS Antibodies**

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor central to innate immunity. Discovered in 2013. cGAS detects aberrant double-stranded DNA (dsDNA) in the cytoplasm, such as viral DNA, bacterial DNA, or mislocalized self-DNA from nuclear or mitochondrial damage. Upon binding dsDNA, cGAS catalyzes the synthesis of cyclic GMP-AMP (cGAMP), a second messenger that activates the STING (stimulator of interferon genes) pathway. This triggers type I interferon and pro-inflammatory cytokine production, mounting an antiviral or antitumor immune response.

cGAS antibodies are vital tools for studying its expression, localization, and activation in physiological and pathological contexts. They enable detection via techniques like Western blot, immunofluorescence, and immunoprecipitation, aiding research into cGAS-mediated immune regulation. Dysregulated cGAS activity is implicated in autoimmune diseases (e.g., lupus, Aicardi-Goutières syndrome), chronic inflammation, and cancer. For instance, uncontrolled cGAS activation by self-DNA drives autoimmunity, while in cancer, cGAS can either promote antitumor immunity or support tumor progression depending on context.

Therapeutic targeting of cGAS is explored to modulate immune responses, with inhibitors and agonists in development. cGAS antibodies also help validate these strategies by assessing target engagement and downstream effects. Their role in elucidating DNA-sensing mechanisms and disease pathways underscores their significance in immunology and translational research.