DYRK1A抗体;DYRK1A Antibody—艾普蒂

The DYRK1A (dual-specificity tyrosine-phosphorylation-regulated kinase 1A) antibody is a critical tool for studying the function and regulation of the DYRK1A protein, a serine/threonine kinase encoded by the *DYRK1A* gene located on human chromosome 21. DYRK1A plays pivotal roles in neurodevelopment, cell cycle regulation, and synaptic plasticity. It is implicated in Down syndrome (trisomy 21), where its overexpression contributes to developmental and cognitive abnormalities, as well as in other neurological disorders, such as Alzheimer’s disease, and cancers. The antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect DYRK1A expression levels, subcellular localization (primarily nuclear), and post-translational modifications. Researchers also employ it to investigate DYRK1A's interactions with substrates involved in signaling pathways (e.g., Wnt, NFAT) and its role in neurogenesis or apoptosis. Due to structural homology among DYRK family members, specificity validation (e.g., using knockout cell lines) is essential to ensure the antibody targets DYRK1A exclusively. Its applications extend to drug discovery, particularly in evaluating kinase inhibitors for therapeutic interventions. Overall, the DYRK1A antibody is indispensable for unraveling the protein’s pathophysiological mechanisms and translational potential.