HNRNPR抗体;HNRNPR Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P13159(HNRNPR Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13159(HNRNPR Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The heterogeneous nuclear ribonucleoprotein R (HNRNPR) is a member of the hnRNP family, which plays critical roles in RNA metabolism, including splicing, transport, stability, and translation. HNRNPR contains RNA-binding domains (RRMs) and is involved in diverse cellular processes, such as mRNA processing, DNA repair, and stress response. Dysregulation of HNRNPR has been linked to neurological disorders (e.g., amyotrophic lateral sclerosis) and cancers, highlighting its functional importance.

HNRNPR antibodies are essential tools for studying its expression, localization, and interactions in cells. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate HNRNPR's role in disease mechanisms or RNA-protein dynamics. Researchers also utilize them to explore post-translational modifications or altered expression patterns under stress or pathological conditions.

Commercially available HNRNPR antibodies are typically raised against specific epitopes, such as the N-terminal or RRM domains, and validated for species reactivity (human, mouse, rat). Challenges include ensuring specificity due to structural similarities among hnRNP family members. Recent studies emphasize the antibody's utility in identifying HNRNPR as a biomarker or therapeutic target, particularly in neurodegeneration and oncology. Proper validation using knockout controls remains crucial for reliable experimental outcomes.