UBIAD1抗体;UBIAD1 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13156(UBIAD1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P13156(UBIAD1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The UBIAD1 (UbiA prenyltransferase domain-containing protein 1) antibody is a tool used to detect and study the UBIAD1 protein, which plays critical roles in cellular metabolism and homeostasis. UBIAD1. also known as TBL2 or SCCD (schnyder corneal dystrophy) protein, is a conserved enzyme localized in the endoplasmic reticulum and mitochondria. It functions as a prenyltransferase involved in vitamin K₂ and coenzyme Q10 biosynthesis, linking it to redox regulation, lipid metabolism, and mitochondrial function. Mutations in the UBIAD1 gene are associated with Schnyder corneal dystrophy (a rare genetic eye disorder) and bladder cancer progression.

UBIAD1 antibodies are widely utilized in research to investigate its expression patterns, subcellular localization, and molecular interactions. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in understanding UBIAD1’s role in diseases and physiological processes. Studies using these antibodies have revealed UBIAD1’s involvement in cholesterol metabolism, Golgi membrane dynamics, and protection against oxidative stress. Commercial UBIAD1 antibodies are typically developed in rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions), with validation in human, mouse, or rat samples. Their applications extend to exploring therapeutic targets for metabolic disorders, cardiovascular diseases, and age-related conditions linked to UBIAD1 dysfunction.