IGSF3抗体;IGSF3 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P13155(IGSF3 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13155(IGSF3 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

IGSF3 (Immunoglobulin Superfamily Member 3) is a transmembrane protein belonging to the immunoglobulin superfamily, characterized by extracellular immunoglobulin-like domains involved in cell-cell adhesion and signaling. Primarily expressed in the brain, testes, and immune tissues, IGSF3 is implicated in neuronal development, spermatogenesis, and immune regulation. Its structure includes a large extracellular region with multiple Ig-like folds, a single transmembrane domain, and a short cytoplasmic tail. While its exact molecular mechanisms remain understudied, IGSF3 is suggested to interact with adhesion molecules (e.g., integrins) and modulate intracellular signaling pathways.

Antibodies targeting IGSF3 are primarily used in research to investigate its expression patterns, subcellular localization, and functional roles. Commercial IGSF3 antibodies are typically developed in rabbits or mice using immunogenic peptide sequences from conserved regions. Validation often involves Western blotting, immunohistochemistry, or immunofluorescence in model systems. Emerging studies link IGSF3 dysregulation to diseases; for example, reduced IGSF3 expression in certain cancers correlates with poor prognosis, while genetic variants are associated with neurodevelopmental disorders. However, the specificity of some IGSF3 antibodies requires rigorous validation due to potential cross-reactivity with structurally similar proteins. Ongoing research aims to clarify its pathophysiological roles and therapeutic potential.