RNF138抗体;RNF138 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13153(RNF138 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13153(RNF138 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The RNF138 antibody is a research tool designed to detect and study the Ring Finger Protein 138 (RNF138), an E3 ubiquitin ligase involved in the ubiquitin-proteasome system. RNF138 plays critical roles in DNA damage repair, cell cycle regulation, and apoptosis by mediating substrate-specific protein ubiquitination. It is particularly noted for its interaction with key DNA repair proteins, such as those in the Fanconi anemia pathway and homologous recombination repair (e.g., BRCA1). Dysregulation of RNF138 has been implicated in cancer progression, with studies showing its overexpression in certain malignancies, including breast and ovarian cancers.

RNF138 antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze protein expression, localization, and interactions in cellular models or clinical samples. These antibodies are typically validated for specificity and sensitivity, often targeting conserved epitopes in human, mouse, or rat RNF138. Commercial variants may include monoclonal or polyclonal formats, with applications spanning basic research to biomarker studies. Recent investigations also explore RNF138's potential as a therapeutic target or prognostic indicator, driving demand for reliable antibody reagents. Proper controls, such as knockout cell lines, are essential to confirm antibody specificity in experimental settings.