SLC15A1抗体;SLC15A1 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13123(SLC15A1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The solute carrier family 15 member 1 (SLC15A1), also known as peptide transporter 1 (PepT1), is a proton-coupled oligopeptide transporter primarily expressed in the intestinal epithelium and renal proximal tubules. It facilitates the uptake of di/tripeptides and peptide-like drugs across cell membranes, playing a critical role in nutrient absorption and pharmacokinetics. SLC15A1 antibodies are immunological tools designed to detect and study the expression, localization, and function of this transporter protein.

These antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate SLC15A1's tissue distribution, regulatory mechanisms, and involvement in diseases. For example, upregulated SLC15A1 expression has been linked to inflammatory bowel disease (IBD) and certain cancers, where it may influence nutrient uptake in tumor microenvironments or modulate drug responsiveness. Researchers also utilize SLC15A1 antibodies to explore its role in oral drug delivery systems and interactions with therapeutic agents.

Most commercially available SLC15A1 antibodies are raised against specific epitopes of the human protein, often targeting extracellular or intracellular domains. Validation includes testing for specificity in knockout models or siRNA-treated cells. Proper antibody selection is crucial for minimizing cross-reactivity with homologous transporters like SLC15A2 (PepT2). As a key mediator of peptide transport, SLC15A1 remains a focal point in studies of intestinal physiology, disease mechanisms, and drug development.