CDH23抗体;CDH23 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13121(CDH23 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

CDH23 (Cadherin-23) is a calcium-dependent transmembrane protein belonging to the cadherin superfamily, which plays critical roles in cell-cell adhesion and mechanosensory signaling. It is particularly vital in the inner ear, where it contributes to the formation of tip links between stereocilia of hair cells, essential for converting sound-induced mechanical vibrations into electrical signals. Mutations in the CDH23 gene are linked to Usher syndrome type 1D (USH1D) and non-syndromic hereditary deafness (DFNB12), highlighting its importance in auditory function. In the retina, CDH23 is involved in photoreceptor cell maintenance, further connecting it to USH1D-associated vision loss.

CDH23 antibodies are essential tools for studying its expression, localization, and function in both auditory and visual systems. These antibodies enable detection via techniques like immunohistochemistry, Western blotting, and immunofluorescence, aiding research on cochlear development, hair cell organization, and disease mechanisms. CDH23's large extracellular domain, containing multiple cadherin repeats, poses challenges for antibody development, requiring careful epitope selection. Commercial CDH23 antibodies are often validated in specific tissues (e.g., mouse inner ear) and applications, necessitating thorough verification for experimental models. Their use extends to diagnostic research, particularly in characterizing genetic hearing loss and Usher syndrome pathologies.