TACR3抗体;TACR3 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13113(TACR3 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The TACR3 antibody targets the tachykinin receptor 3 (TACR3), also known as the neurokinin 3 receptor (NK3R), a G protein-coupled receptor that binds neurokinin B (NKB), a neuropeptide belonging to the tachykinin family. TACR3 is widely expressed in the central and peripheral nervous systems, with notable roles in reproductive physiology, mood regulation, and endocrine function. It is particularly abundant in hypothalamic regions, where it regulates gonadotropin-releasing hormone (GnRH) secretion, influencing puberty onset and reproductive hormone dynamics. Dysregulation of TACR3/NKB signaling has been implicated in conditions such as hypogonadotropic hypogonadism, polycystic ovary syndrome (PCOS), and mood disorders like depression and anxiety.

TACR3 antibodies are critical tools for studying receptor localization, expression levels, and signaling mechanisms in both normal and pathological states. They are employed in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize receptor distribution in tissues or assess protein expression changes under experimental conditions. Recent research has also explored TACR3's potential as a therapeutic target, with antagonists investigated for treating menopausal hot flashes and hyperkinetic movement disorders. The development and validation of TACR3 antibodies continue to advance understanding of its physiological roles and its involvement in disease pathways, bridging gaps between molecular studies and clinical applications.