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  • RCOR2抗体;RCOR2 Antibody—艾普蒂
  • RCOR2抗体;RCOR2 Antibody—艾普蒂
  • RCOR2抗体;RCOR2 Antibody—艾普蒂

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RCOR2抗体;RCOR2 Antibody—艾普蒂

Rabbit Polyclonal RCOR2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-28

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
RCOR2抗体
英文名称：
Rabbit Polyclonal RCOR2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 7072 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
RCOR2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human RCOR2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13111(RCOR2 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13111(RCOR2 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于RCOR2抗体的参考文献示例(内容为模拟生成，建议通过学术数据库验证原文)：

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1. **文献名称**: *RCOR2 mediates REST-dependent transcriptional repression in neural stem cells*

**作者**: Smith A, et al.

**摘要**: 本研究利用RCOR2抗体通过ChIP-seq和免疫沉淀技术，揭示了RCOR2与REST蛋白协同抑制神经元基因的机制，表明其在神经干细胞分化的表观遗传调控中起关键作用。

2. **文献名称**: *Aberrant RCOR2 expression promotes tumorigenesis in glioblastoma*

**作者**: Chen L, et al.

**摘要**: 通过Western blot和免疫组化分析，研究发现RCOR2在胶质母细胞瘤中表达下调，其缺失导致肿瘤抑制基因沉默，提示RCOR2可能作为癌症治疗的新靶点。

3. **文献名称**: *Dynamic interaction between RCOR2 and LSD1 in chromatin remodeling*

**作者**: Tanaka K, et al.

**摘要**: 利用RCOR2抗体进行共聚焦显微镜和Co-IP实验，证实RCOR2与LSD1形成复合物，调控组蛋白去甲基化，影响胚胎干细胞的自我更新和分化。

4. **文献名称**: *RCOR2 antibody validation for epigenetic studies in human tissues*

**作者**: Patel R, et al.

**摘要**: 该文献系统验证了RCOR2抗体的特异性，通过敲除实验和质谱分析确认其适用于染色质免疫共沉淀(ChIP)及免疫荧光，为后续表观遗传研究提供可靠工具。

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建议通过PubMed或Google Scholar搜索具体文献，以“RCOR2 antibody”、“RCOR2 function”等关键词获取最新研究。

       

背景信息

The RCOR2 antibody is a valuable tool for studying the REST corepressor 2 (RCOR2) protein, a member of the CoREST family. RCOR2. also known as CoREST2. functions as a transcriptional coregulator by interacting with REST (RE1-silencing transcription factor) and other chromatin-modifying complexes. It plays a critical role in repressing neuronal gene expression in non-neuronal cells and stem cells, contributing to cellular differentiation and development. RCOR2 forms complexes with histone demethylases (e.g., LSD1/KDM1A) and histone deacetylases (e.g., HDAC1/2), enabling chromatin remodeling and epigenetic regulation. Its involvement in neurogenesis, stem cell maintenance, and cancer pathways has made it a focus in developmental biology and oncology research.

The RCOR2 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to detect protein expression, localization, and DNA-binding activity. Researchers employ it to explore RCOR2's role in diseases, particularly cancers where dysregulated RCOR2 expression correlates with tumor progression or metastasis. Specificity validation via knockout/knockdown controls is essential, as cross-reactivity with other CoREST family members (e.g., RCOR1) may occur. Commercial RCOR2 antibodies are typically raised against conserved epitopes, such as the N-terminal or C-terminal regions, with host species (rabbit, mouse) and clonality (monoclonal/polyclonal) options available. Recent studies also highlight its potential as a therapeutic target in neurological disorders and malignancies.

       
RCOR2抗体;RCOR2;RCOR2 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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