RCOR1抗体;RCOR1 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: PC-3 and 231 cell lysates, Primary antibody: P13110(RCOR1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13110(RCOR1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The RCOR1 antibody is a crucial tool for studying the REST corepressor 1 (RCOR1), a protein integral to the CoREST transcriptional repressor complex. RCOR1 interacts with histone-modifying enzymes like LSD1 (KDM1A) and histone deacetylases (HDAC1/2), enabling chromatin remodeling and epigenetic regulation of gene expression. It plays a pivotal role in repressing neuronal genes in non-neuronal cells, stem cell maintenance, and cellular differentiation. Dysregulation of RCOR1 is implicated in cancers, neurodevelopmental disorders, and neurodegenerative diseases, making it a focus of research in oncology and neuroscience.

RCOR1 antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and chromatin immunoprecipitation (ChIP) to detect RCOR1 expression, localization, and DNA-binding interactions. These antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of human RCOR1. Validation includes testing for specificity via knockout cell lines or siRNA knockdown. Researchers rely on RCOR1 antibodies to explore its role in gene silencing mechanisms, cancer progression (e.g., suppressing tumor suppressors), and neural development, offering insights into therapeutic targets for diseases linked to epigenetic dysregulation.