COP1抗体;COP1 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13109(COP1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13109(COP1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of COP1 Antibody**

COP1 (Constitutive Photomorphogenic 1) is an evolutionarily conserved E3 ubiquitin ligase initially identified in plants, where it regulates light-dependent developmental processes by targeting photomorphogenesis-promoting transcription factors for proteasomal degradation. In mammals, COP1 retains its role as a regulator of ubiquitin-mediated protein turnover, influencing diverse cellular processes, including stress responses, metabolism, and tumorigenesis. Notably, COP1 interacts with critical oncogenic or tumor-suppressive substrates, such as c-Jun, ETS family members, and p53. modulating their stability and activity.

Antibodies targeting COP1 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to investigate COP1's regulatory roles in cellular pathways. Research has highlighted COP1's dual role in cancer, acting as either an oncogene or tumor suppressor depending on cellular context and substrate specificity. For instance, COP1-mediated degradation of c-Jun can suppress tumor growth, while its loss or mutation may stabilize oncoproteins, promoting malignancy.

COP1 antibodies also aid in exploring its involvement in metabolic disorders and immune regulation, making them valuable in both basic and translational research. Their specificity and reliability are critical for dissecting COP1's complex functions across species and disease models.