CARD16抗体;CARD16 Antibody—艾普蒂 新品

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: HEPG2 cell lysate, Primary antibody: P13108(CARD16 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 60 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13108(CARD16 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13108(CARD16 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The CARD16 antibody targets the caspase recruitment domain-containing protein 16 (CARD16), also known as COP1 or pseudo-ICE, a member of the CARD protein family. CARD16 is involved in regulating inflammatory and apoptotic pathways by modulating caspase activation and NF-κB signaling. Structurally, it contains a CARD domain, enabling interactions with other CARD-containing proteins like caspase-1 and NLRP3. Unlike other CARD family members, CARD16 lacks a pyrin domain, which influences its role as a regulatory molecule rather than a direct inflammasome component.

Antibodies against CARD16 are primarily used in research to study its expression, localization, and function in immune regulation. Studies suggest CARD16 acts as an endogenous inhibitor of inflammasome activity, competing for binding with pro-inflammatory signaling molecules. This regulatory role links CARD16 to autoimmune diseases, cancer, and inflammatory disorders. For example, reduced CARD16 expression has been associated with hyperactive NLRP3 inflammasome responses in conditions like rheumatoid arthritis or sepsis.

Current research focuses on understanding its therapeutic potential, including modulating CARD16 levels to control excessive inflammation. Commercial CARD16 antibodies enable detection via Western blot, immunohistochemistry, or immunofluorescence, aiding mechanistic studies in cellular and animal models. However, its precise physiological and pathological roles remain under investigation, highlighting the need for further exploration of its interactions and regulatory networks.