CHURC1抗体;CHURC1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13082(CHURC1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13082(CHURC1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The CHURC1 (Churchill domain containing 1) antibody is a tool used to detect the CHURC1 protein, a nuclear protein implicated in transcriptional regulation and cellular differentiation. Initially identified in studies of neural development, CHURC1 is critical for neural crest cell migration and differentiation. It contains a conserved Churchill domain, which may mediate interactions with transcriptional regulators or chromatin modifiers. Dysregulation of CHURC1 has been linked to neurodevelopmental disorders, neural tube defects, and cancers, including neuroblastoma, lung cancer, and breast cancer, where its expression often correlates with tumor progression or metastasis.

CHURC1 antibodies, typically raised in rabbits or mice, enable researchers to study the protein's expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies have been instrumental in uncovering CHURC1's role in modulating signaling pathways such as Wnt and FGF, as well as its interplay with other differentiation-associated factors. Recent studies also suggest CHURC1 may act as a tumor suppressor or oncogene in a context-dependent manner, highlighting its potential as a therapeutic target or diagnostic biomarker. Validation of CHURC1 antibody specificity remains crucial, as cross-reactivity with structurally similar proteins could lead to misinterpretation of experimental results.