HAUS2抗体;HAUS2 Antibody—艾普蒂 新品

+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse pancreas tissue lysate, Primary antibody: P13068(HAUS2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13068(HAUS2 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The HAUS2 antibody is a research tool designed to target the HAUS2 protein, a critical component of the HAUS (HAUS Augmin-like complex) family involved in microtubule organization during cell division. The HAUS complex, comprising eight subunits (HAUS1-HAUS8), facilitates spindle assembly by promoting microtubule branching and nucleation, ensuring proper mitotic spindle formation and chromosomal segregation. HAUS2. also known as DGT6. plays a key role in recruiting γ-tubulin ring complexes to spindle microtubules, enhancing their stability and density. This function is evolutionarily conserved across eukaryotes, reflecting its fundamental role in cell cycle regulation.

Antibodies against HAUS2 are widely used in molecular biology to study its expression, localization, and interactions. They enable techniques like Western blotting, immunofluorescence, and co-immunoprecipitation, aiding in the investigation of mitotic mechanisms, spindle dynamics, and cell division defects. HAUS2 dysregulation has been linked to mitotic errors, genomic instability, and diseases such as cancer, making its antibody valuable for both basic research and clinical studies.

Most HAUS2 antibodies are raised in rabbits or mice using immunogenic peptide sequences specific to conserved regions of the protein. Validation typically includes knockout cell lines or siRNA knockdown to confirm specificity. These reagents are essential for elucidating HAUS2's contributions to cellular homeostasis and its potential as a therapeutic target in pathologies linked to mitotic dysfunction.