CEP104抗体;CEP104 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13066(CEP104 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The CEP104 antibody is a research tool designed to target Centrosomal Protein 104 (CEP104), a conserved protein localized to centrioles and critical for cilia formation, microtubule stability, and centriolar integrity. Discovered for its role in regulating axonemal microtubule dynamics, CEP104 is particularly important in primary cilia, sensory organelles involved in signaling pathways like Hedgehog and Wnt. Dysregulation of CEP104 is linked to ciliopathies, such as Joubert syndrome, and cancers, where altered cilia function or centrosomal abnormalities may drive tumor progression.

CEP104 antibodies are widely used in immunofluorescence, Western blotting, and immunoprecipitation to study protein localization, expression levels, and interactions in cellular models. They help elucidate mechanisms underlying cilia-related disorders and centrosome amplification in cancer. Recent studies also explore CEP104's potential as a biomarker for ciliopathies or therapeutic targeting. However, functional studies remain ongoing, with efforts focused on understanding its post-translational modifications and role in cellular responses to mechanical stress.

These antibodies are vital for advancing research in developmental biology, neurobiology, and oncology, offering insights into disease mechanisms and guiding future therapeutic strategies.