GULP1抗体;GULP1 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P13058(GULP1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The GULP1 (Growth hormone Upregulated Liver-specific Protein 1) antibody is a tool used to study the GULP1 protein, an adaptor molecule involved in cellular processes like apoptosis, phagocytosis, and signal transduction. GULP1 contains a phosphotyrosine-binding (PTB) domain, enabling interactions with receptors, including those in the low-density lipoprotein receptor family. It is best known for its role in phagocytic clearance of apoptotic cells, acting downstream of the engulfment receptor CED-1/DRAPER. Research highlights its involvement in TGF-β signaling, lipid metabolism, and neuronal development.

GULP1 dysregulation has been linked to neurodegenerative disorders (e.g., Alzheimer’s disease) and cancers (e.g., breast and ovarian), where it may act as a tumor suppressor or promoter depending on context. The antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect GULP1 expression, localization, and interactions in tissues or cell lines. Its development has advanced studies exploring molecular mechanisms of cell clearance, cancer progression, and neural homeostasis. Understanding GULP1’s functions via antibody-based assays may provide insights into therapeutic strategies for related diseases.