CDC20B抗体;CDC20B Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13047(CDC20B Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

CDC20B antibody is a research tool used to detect the Cell Division Cycle 20 homolog B (CDC20B), a protein belonging to the CDC20 family involved in cell cycle regulation. CDC20B, also known as CDC20-2 or CDCA1. shares structural homology with CDC20. a critical activator of the anaphase-promoting complex/cyclosome (APC/C) that drives mitotic progression by targeting securin and cyclin B for degradation. However, unlike its well-characterized paralog CDC20. CDC20B's biological functions remain less understood. Studies suggest it may play specialized roles in meiosis, tissue-specific mitotic regulation, or non-canonical APC/C interactions, particularly in germ cells, neural tissues, or certain cancers.

The CDC20B antibody enables researchers to investigate the protein's expression patterns, subcellular localization, and interactions through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Its development stems from the need to distinguish CDC20B from CDC20 in experimental models, given their overlapping molecular weights (~55-60 kDa) and sequence similarities. Some studies report CDC20B's potential involvement in cell cycle checkpoint control, DNA damage response, or cancer progression, though findings vary across cell types and contexts. Commercial antibodies are typically raised against unique peptide sequences within the N-terminal or central regions of human CDC20B. Validation remains crucial due to occasional cross-reactivity concerns and limited functional characterization in the literature. Ongoing research using this antibody aims to clarify CDC20B's contribution to developmental processes, reproductive biology, and diseases linked to cell cycle dysregulation.