CDC14A抗体;CDC14A Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13045(CDC14A Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13045(CDC14A Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The CDC14A antibody is a crucial tool for studying the dual-specificity phosphatase CDC14A, a key regulator of cell cycle progression. CDC14A, part of the conserved CDC14 phosphatase family, plays pivotal roles in mitotic exit, centrosome maturation, and DNA damage response by dephosphorylating cell cycle-related substrates such as CDK1 and certain E3 ubiquitin ligases. It counteracts cyclin-dependent kinase (CDK) activity to ensure orderly transitions between cell cycle phases. Research links CDC14A dysfunction to genomic instability, developmental disorders, and cancers, making it a focus in oncology and cell biology studies.

The CDC14A antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression, subcellular localization (e.g., nucleolar distribution during interphase), and interaction partners. Its specificity varies across commercial clones, requiring validation via knockout cell lines or siRNA knockdown controls. Studies employing this antibody have revealed CDC14A's context-dependent roles—while essential in some cancers, its loss may paradoxically drive malignancy in others. Recent work also implicates CDC14A in cilia disassembly and neurological development. Researchers prioritize antibodies validated in peer-reviewed publications to ensure reproducibility, particularly given CDC14A's overlapping functions with its paralog CDC14B. Proper controls are critical due to potential cross-reactivity or batch variability.