CAPN9抗体;CAPN9 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13014(CAPN9 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13014(CAPN9 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The calpain 9 (CAPN9) antibody is a tool used to study the CAPN9 protein, a member of the calpain family of calcium-dependent cysteine proteases. Calpains regulate diverse cellular processes, including cytoskeletal remodeling, signal transduction, and apoptosis. CAPN9. specifically, is distinguished by its tissue-specific expression, predominantly in the gastrointestinal tract, particularly the stomach. It forms a functional heterodimer with CAPN1 (calpain 1), known as G-calpain, which is hypothesized to play a role in gastric mucosal defense and digestion by modulating protease activity in acidic environments.

CAPN9 antibodies are critical for investigating its expression patterns, subcellular localization, and interactions in physiological and pathological contexts. Research suggests CAPN9 may be implicated in diseases such as gastric cancer, inflammatory bowel disease, and Helicobacter pylori infections, where dysregulation of protease activity contributes to pathogenesis. Additionally, CAPN9 has been linked to cell survival and apoptosis in certain cancers, highlighting its potential as a therapeutic target or biomarker.

These antibodies enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the validation of CAPN9’s roles in vitro and in vivo. Despite progress, the precise mechanisms of CAPN9 in health and disease remain understudied, necessitating further exploration using targeted molecular tools like CAPN9-specific antibodies.