CACNG5抗体;CACNG5 Antibody—艾普蒂

The CACNG5 antibody targets the CACNG5 protein, a member of the voltage-dependent calcium channel gamma subunit family. CACNG5 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5) is a transmembrane protein that regulates the trafficking and biophysical properties of calcium channels, particularly Cav1 (L-type) and Cav2 (P/Q, N, R-type) channels. It is expressed in the central nervous system, with high levels in the cerebellum, hippocampus, and cerebral cortex, suggesting roles in synaptic plasticity, neurotransmitter release, and neuronal excitability. Dysregulation of CACNG5 has been linked to neurological disorders, including epilepsy, neuropathic pain, and neuropsychiatric conditions. The CACNG5 antibody is widely used in research to study protein localization, expression patterns, and interaction networks via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Its specificity is often validated using knockout controls or siRNA-mediated knockdown. Studies utilizing this antibody have contributed to understanding calcium signaling in neuronal development, disease mechanisms, and potential therapeutic targeting. Recent work also explores CACNG5's non-canonical roles, such as modulating AMPA receptor function, highlighting its broader impact on synaptic transmission beyond calcium channel regulation.