CACNA1H抗体;CACNA1H Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13001(CACNA1H Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13001(CACNA1H Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The CACNA1H gene encodes the α1H subunit of voltage-gated calcium channels, specifically the Cav3.2 T-type calcium channel. These channels mediate low-voltage-activated calcium currents critical for regulating cellular excitability, particularly in excitable cells like neurons, cardiac myocytes, and endocrine cells. CACNA1H-associated T-type channels contribute to rhythmic firing, burst activity, and calcium signaling in physiological processes such as hormone secretion, neuronal communication, and cardiac pacemaking.

CACNA1H antibodies are immunological tools developed to detect and study the expression, localization, and function of the Cav3.2 protein. Research has linked CACNA1H mutations or dysregulation to several disorders, including childhood absence epilepsy, autism spectrum disorders, and primary aldosteronism. Antibodies targeting CACNA1H enable investigations into these pathologies, aiding in understanding how channel dysfunction alters cellular physiology. For example, they are used in techniques like Western blotting, immunohistochemistry, or immunofluorescence to assess protein levels in disease models or patient tissues.

Recent studies also explore CACNA1H's role in pain signaling and neurodevelopmental conditions, highlighting its broader therapeutic relevance. However, antibody specificity remains a consideration, as cross-reactivity with other calcium channel subtypes (e.g., Cav3.1 or Cav3.3) may occur. Validated CACNA1H antibodies are thus essential for accurate mechanistic insights, supporting both basic research and potential clinical applications in channelopathy-related diseases.