CACNA1B抗体;CACNA1B Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13000(CACNA1B Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The CACNA1B gene encodes the α1B subunit of voltage-gated calcium channel Cav2.2 (N-type), which regulates calcium influx in neurons, particularly at presynaptic terminals, enabling neurotransmitter release. Antibodies targeting CACNA1B are associated with autoimmune and paraneoplastic neurological disorders. These autoantibodies disrupt Cav2.2 function, impairing synaptic transmission and leading to symptoms like cerebellar ataxia, neuromuscular dysfunction, or autonomic instability.

CACNA1B antibodies are often detected in conditions such as autoimmune cerebellar ataxia, Lambert-Eaton myasthenic syndrome (LEMS), and rare paraneoplastic syndromes linked to small-cell lung carcinoma or neuroendocrine tumors. Their presence may indicate an underlying malignancy, warranting cancer screening. Detection methods include cell-based assays, immunohistochemistry, or immunoblotting using recombinant Cav2.2 proteins.

Research suggests these antibodies may directly block calcium channels or trigger complement-mediated neuronal damage. Clinical outcomes vary; some patients respond to immunotherapy (steroids, IVIg) or tumor resection, while others develop progressive neurological deficits. Studies continue to explore their pathogenic mechanisms and diagnostic utility in autoimmune neurology.