URI1抗体;URI1 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 and 293T cell lysates, Primary antibody: P12987(URI1 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 50 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12987(URI1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12987(URI1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The URI1 antibody is a research tool designed to detect URI1 (Unconventional prefoldin RPB5 Interactor 1), a protein involved in diverse cellular processes, including transcriptional regulation, stress response, and chromatin remodeling. URI1. also known as RMP or SPRETUS19. functions as part of the prefoldin-like complex, acting as a molecular chaperone that stabilizes RNA polymerase II subunits and modulates transcriptional activity. It interacts with components of the PFDN family and other partners like RPB5 (POLR2E), linking it to pathways such as mTOR signaling and mitochondrial function.

First identified in yeast, URI1 is evolutionarily conserved and plays roles in embryogenesis, cell proliferation, and tumorigenesis. Dysregulation of URI1 has been implicated in cancers, metabolic disorders, and neurological diseases, making it a potential therapeutic target. The URI1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression patterns, subcellular localization (primarily cytoplasmic and nuclear), and interactions in both normal and pathological contexts. Its development has facilitated insights into URI1's dual role as an oncogene or tumor suppressor, depending on cellular context, and its involvement in stress adaptation mechanisms. Validation of antibody specificity through knockout controls remains critical due to cross-reactivity risks.