ATP5MPL抗体;ATP5MPL Antibody—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-7: 293T and RAW264.7 cell，Human fetal brain tissue，Jurkat and 231 cell，Human heart tissue，Hela cell lysates, Primary antibody: P12980(ATP5MPL Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12980(ATP5MPL Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12980(ATP5MPL Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The ATP5MPL antibody targets the ATP synthase membrane subunit 6.8PL (ATP5MPL), a critical component of mitochondrial ATP synthase (Complex V), the enzyme responsible for ATP production during oxidative phosphorylation. ATP5MPL, also referred to as ATP5PD or subunit d, is a nuclear-encoded accessory subunit that stabilizes the enzyme’s structure and facilitates proton transport across the mitochondrial inner membrane. This antibody is commonly used in research to study mitochondrial function, energy metabolism, and diseases linked to mitochondrial dysfunction, such as neurodegenerative disorders, cancer, and metabolic syndromes.

As a tool for applications like Western blotting, immunohistochemistry, and immunofluorescence, the ATP5MPL antibody helps detect protein expression levels, subcellular localization, and potential post-translational modifications. Its specificity enables researchers to investigate how ATP5MPL expression varies under pathological conditions or experimental manipulations, such as hypoxia, nutrient stress, or genetic knockdown. Validated in multiple species and sample types (tissues, cell lines), the antibody contributes to understanding mitochondrial dynamics, bioenergetic adaptations, and therapeutic targeting of mitochondrial pathways. Its role in elucidating ATP synthase assembly and activity further supports studies on aging, apoptosis, and cellular stress responses.