BRIX1抗体;BRIX1 Antibody—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and HepG2 cell lysates, Primary antibody: P12962(BRIX1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

The BRIX1 antibody is a research tool designed to detect and study the BRIX1 protein, also known as BRX1 or BXDC2. which belongs to the Brix domain-containing protein family. BRIX1 is evolutionarily conserved and plays a critical role in ribosome biogenesis, specifically in the processing and maturation of ribosomal RNA (rRNA). It localizes to the nucleolus, where it contributes to the assembly of ribosomal subunits by facilitating rRNA structural modifications. Dysregulation of BRIX1 has been implicated in developmental disorders and cellular stress responses due to its essential role in protein synthesis machinery.

The antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate BRIX1 expression, subcellular localization, and interactions. Researchers employ it to explore links between BRIX1 dysfunction and diseases, such as cancer or ribosomopathies, where altered ribosome biogenesis drives pathological processes. Commercial BRIX1 antibodies are typically raised in rabbits or mice, validated for specificity against recombinant or endogenous proteins.

Understanding BRIX1’s mechanisms through antibody-based studies provides insights into ribosome assembly pathways and potential therapeutic targets for diseases tied to translational defects. Its utility spans basic cell biology, molecular diagnostics, and drug discovery.