BMPER抗体;BMPER Antibody—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse small intestines tissue lysate, Primary antibody: P10185(PEPD Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10185(PEPD Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The BMPER (Bone Morphogenetic Protein-Binding Endothelial Regulator) protein is a secreted glycoprotein that modulates signaling pathways involving bone morphogenetic proteins (BMPs), key members of the TGF-β superfamily. BMPs regulate diverse cellular processes, including embryogenesis, angiogenesis, and tissue homeostasis. BMPER acts as a context-dependent regulator—enhancing or inhibiting BMP signaling—by directly binding BMP ligands and influencing their interaction with receptors or extracellular antagonists. This dual role positions BMPER as a critical player in developmental and pathological conditions, particularly in vascular development and endothelial cell behavior.

BMPER antibodies are essential tools for studying its expression, localization, and function. They enable detection and quantification in techniques like Western blotting, immunohistochemistry, and ELISA. Research using these antibodies has linked BMPER dysregulation to diseases such as cancer (e.g., tumor angiogenesis), cardiovascular disorders (e.g., atherosclerosis), and congenital anomalies like 5q14.3 deletion syndrome, characterized by neurovascular defects. Animal studies further highlight its role in embryogenesis, with BMPER knockout models showing impaired vascular branching.

Current studies focus on elucidating BMPER's molecular mechanisms and therapeutic potential, particularly in targeting BMP-related pathways. Antibodies against BMPER remain pivotal in unraveling its complex biology and translational applications.