BMP1抗体;BMP1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12952(BMP1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The BMP1 (Bone Morphogenetic Protein 1) antibody is a tool used to study the function and expression of BMP1. a metalloprotease critical in extracellular matrix (ECM) formation and tissue development. Unlike other BMP family members (e.g., BMP2–7), which are growth factors in the TGF-β superfamily, BMP1 is a protease that activates precursors of collagen and other ECM proteins, facilitating their assembly into functional matrices. It plays a key role in cleaving procollagen C-propeptides, enabling fibril formation, and processes proteins like laminins and lysyl oxidases, influencing tissue repair and fibrosis.

BMP1 antibodies are widely used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They help investigate BMP1's involvement in diseases such as fibrosis, cancer metastasis, and connective tissue disorders. Dysregulation of BMP1 is linked to abnormal collagen deposition, making it a potential therapeutic target. Studies also explore its interaction with other proteases (e.g., Tolloid-like enzymes) and its role in developmental pathways.

When selecting BMP1 antibodies, specificity is crucial due to structural similarities with related proteases. Researchers utilize these antibodies to validate gene-editing outcomes, assess tissue-specific expression, or screen inhibitors for drug development. Understanding BMP1’s mechanisms through antibody-based assays contributes to insights into ECM remodeling and related pathologies.